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探索在病理情况（特别是自闭症础厂顿蝉和阿尔茨海默病础顿）下大脑神经环路的变化。在之前的工作中，利用双光子体在体成像技术，发现础厂顿小鼠模型的初级视觉皮层和础顿小鼠的前额叶皮层的神经环路功能存在缺陷。在未来，计划运用清醒状态下的双光子在体成像技术研究神经精神疾病动物模型的神经环路的时空特性，寻找疾病的神经环路机制。

主要研究论文

Li Y#, Tian Y#, Pei X#, Zheng P, Miao L, Li L, Luo C, Zhang P, Jiang B, Teng J*, Huang N*, Chen J*. (2023). l. SCG10 is required for peripheral axon maintenance and regeneration in mice. J Cell Sci. 136(12):jcs260490.(#co-first authors)

Su F#, Tian Y#*. (2022) Non-rigid Registration for Two-photon Imaging Using Triangulation and Piecewise Affine Transformation. Neuroscience. 491:1-12.(#co-first authors) (*corresponding authors)

Yang C#, Tian Y#, Su F#, Wang Y#, Liu M#, Wang H#, Cui Y#, Yuan P, Li X, Li A, Gong H, Luo Q, Zhu D, Cao P, Liu Y, Wang X, Luo MH, Xu F, Xiong W, Wang L, Li XY, Zhang C*. (2021) Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome. Protein Cell. 13(3):203-219. (#co-first authors)

Wang Y#, Su F#, Wang S#, Yang C#, Tian Y#, Yuan P#, Liu X, Xiong W*, Zhang C*. (2019) Efficient implementation of convolutional neural networks in the data processing of two-photon in vivo imaging. Bioinformatics.35(17):3208-3210. (#co-first authors)

Tian Y#, Yang C#, Cui Y#, Su F#, Wang Y#, Wang Y#, Yuan P, Shang S, Li H, Zhao J, Zhu D, Tang S, Cao P, Liu Y, Wang X, Wang L, Zeng W, Jiang H, Zhao F, Luo M, Xiong W, Qiu Z*, Li XY*, Zhang C*. (2018) An Excitatory Neural Assembly Encodes Short-Term Memory in the Prefrontal Cortex. Cell Reports. 22(7):1734-1744. (#co-first authors)

Tian Y#, Yang C#, Shang S#, Cai Y#, Deng X#, Zhang J, Shao F, Zhu D, Liu Y, Chen G, Liang J*, Sun Q*, Qiu Z*, Zhang C*. (2017) Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats. Frontiers in Molecular Neuroscience.10:269. (#co-first authors)

合作发表论文

Wei M, Huang X, Liao L, Tian Y, Zheng X. (2023). SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer. Cancer Res. 83(17):2908-2923.

Lu K, Li C, Liu J, Wang J, Li Y, He B, Li J, Zhang X, Wei M, Tian Y, Zhang R, Zhang C, & Zhang Y. (2023). Impairments in endogenous AMPA receptor dynamics correlates with learning deficits in Alzheimer's disease model mice.Proc Natl Acad Sci U S A. 120(40), e2303878120.

Du L, Li J, Tian Y, Feng R. (2023). Pleckstrin-2-promoted PPM1B degradation plays an important role in transforming growth factor-β-induced breast cancer cell invasion and metastasis. Cancer Sci. 114(6):2429-2444.

Jiang LX, Huang GD, Tian YL, et al. (2023). Diminished activation of excitatory neurons in the prelimbic cortex leads to impaired working memory capacity in mice. BMC Biol. 21(1):171.

Zhao Y, Huang X, Zhu D, Wei M, Luo J, Yu S, Tian Y, Zheng X. (2022) Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. Cell Death and Differentiation. 2022 Jun 29. doi: 10.1038/s41418-022-01036-6.

Ma D, Wang F, Wang R, Hu Y, Chen Z, Huang N, Tian Y, Xia Y, Teng J, Chen J. (2022) α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization. Elife. 11:e73252.

Zhu D, Xu R, Huang X, Tang Z, Tian Y, Zhang J, Zheng X. (2021) Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1. Cell Death and Differentiation. 28(6):1773-1789.

Xu R, Yu S, Zhu D, Huang X, Xu Y, Lao Y, Tian Y, Zhang J, Tang Z, Zhang Z, Yi J, Zhu HH, Zheng X. (2019) hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy. Nature Communications.10(1):3812.

Zhou K, Ding Y, Vuletic I, Tian Y, Li J, Liu J, Huang Y, Sun H, Li C, Ren Q, Lu Y. (2018) In vivo long-term investigation of tumor bearing mKate2 by an in-house fluorescence molecular imaging system. Biomedical Engineering Online. 17(1):187.

Ji Y, Yang C, Tang Z, Yang Y, Tian Y, Yao H, Zhu X, Zhang Z, Ji J, Zheng X. (2017) Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation. Nature Communications. 8:15308.

Zeng WB, Jiang HF, Gang YD, Song YG, Shen ZZ, Yang H, Dong X, Tian YL, Ni RJ, Liu Y, Tang N, Li X, Jiang X, Gao D, Androulakis M, He XB, Xia HM, Ming YZ, Lu Y, Zhou JN, Zhang C, Xia XS, Shu Y, Zeng SQ, Xu F, Zhao F, Luo MH. (2017) Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129. Molecular Neurodegeneration. 12(1):38.

Yu J, Ju Y, Zhao L, Chu X, Yang W, Tian Y, Sheng F, Lin J, Liu F, Dong Y, Hou Y. (2016) Multistimuli-Regulated Photochemothermal Cancer Therapy Remotely Controlled via Fe5C2 Nanoparticles. ACS Nano. 10(1):159-69.

Bai D, Zhang J, Li T, Hang R, Liu Y, Tian Y, Huang D, Qu L, Cao X, Ji J, Zheng X. (2016) The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth. Nature Communications.7:12310.

Weng R, Shen S, Burton C, Yang L, Nie H, Tian Y, Bai Y, Liu H. (2016) Lipidomic profiling of tryptophan hydroxylase 2 knockout mice reveals novel lipid biomarkers associated with serotonin deficiency. Analytical and Bioanalytical Chemistry. 408(11):2963-73.

Weng R, Shen S, Tian Y, Burton C, Xu X, Liu Y, Chang C, Bai Y, Liu H. (2015) Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency. Scientific Reports. 5:11864.

Weng R, Shen S, Yang L, Li M, Tian Y, Bai Y, Liu H. (2015) Lipidomic analysis of p-chlorophenylalanine-treated mice using continuous-flow two-dimensional liquid chromatography/quadrupole time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry. 2015 Aug 30;29(16):1491-500.

Zhong W, Zhu H, Sheng F, Tian Y, Zhou J, Chen Y, Li S, Lin J. (2014) Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells. Autophagy. 10(7):1285-300.

Shen H, Zhu H, Song M, Tian Y, Huang Y, Zheng H, Cao R, Lin J, Bi Z, Zhong W. (2014) A selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells. BMC Cancer. 14:629.

Zhang Z, Jia C, Hu Y, Sun L, Jiao J, Zhao L, Zhu D, Li J, Tian Y, Bai H, Li R, Hu J. (2012) The estrogenic potential of salicylate esters and their possible risks in foods and cosmetics. Toxicology Letters. 209(2):146-53.